Clinical significance of hematuria in patients on anticoagulant therapy

J Urol. 1987 May;137(5):923-5. doi: 10.1016/s0022-5347(17)44295-9.


We evaluated 29 consecutive patients in whom gross or microscopic hematuria developed while they were on heparin or warfarin anticoagulant therapy. Patients who had bleeding as a result of anticoagulant overdosage and/or from an additional organ system(s) other than the urinary tract were excluded from this review. Significant pathological findings consisting of carcinoma, calculi, renal infarction, infection, benign prostatic hyperplasia and/or adult polycystic renal disease were identified in 17 patients. Insignificant or incidental pathological findings classified as posterior urethritis, simple renal cyst or renal scarring were noted in 6 patients. No pathological condition was found in the remaining 6 patients. We conclude that a thorough and appropriate evaluation of the urinary tract should be conducted in patients on anticoagulant therapy who have gross or microscopic hematuria, since a pathological lesion of variable clinical significance often is discovered.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Hematuria / chemically induced
  • Hematuria / etiology*
  • Heparin / therapeutic use
  • Heparin / toxicity*
  • Humans
  • Kidney Diseases / complications*
  • Male
  • Middle Aged
  • Urinary Calculi / complications*
  • Urologic Neoplasms / complications*
  • Warfarin / therapeutic use
  • Warfarin / toxicity*


  • Warfarin
  • Heparin