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. 2022 Jul 7;387(1):86-88.
doi: 10.1056/NEJMc2206576. Epub 2022 Jun 22.

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

Nicole P Hachmann  1 , Jessica Miller  1 , Ai-Ris Y Collier  1 , John D Ventura  1 , Jingyou Yu  1 , Marjorie Rowe  1 , Esther A Bondzie  1 , Olivia Powers  1 , Nehalee Surve  1 , Kevin Hall  1 , Dan H Barouch  1
Affiliations

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

Nicole P Hachmann et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Omicron Subvariant Mutations and Neutralizing Antibody Responses.
Panel A shows the lineage of mutations that have been identified in the omicron BA.1, BA.2, BA.2.12.1, and BA.4 or BA.5 subvariants of SARS-CoV-2, as compared with the reference WA1/2020 isolate. BA.4 and BA.5 have identical sequences of the spike protein and thus have been grouped together. FP denotes fusion peptide, HR1 heptad repeat 1, HR2 heptad repeat 2, NTD N-terminal domain, RBD receptor-binding domain, RBM receptor-binding motif, SD1 subdomain 1, and SD2 subdomain 2. Panel B shows neutralizing antibody titers as determined by luciferase-based pseudovirus neutralization assays in samples obtained from 27 participants 6 months after receipt of the two-dose BNT162b2 messenger RNA vaccine series and 2 weeks after the third (booster) dose. Panel C shows neutralizing antibody titers in participants who had been infected with the BA.1 or BA.2 subvariant. All the infected participants had been vaccinated except for 1 participant who had a negative neutralizing antibody titer. In 9 participants, two or three time points after infection are shown. Neutralizing antibody titers were measured against the SARS-CoV-2 reference isolate WA1/2020 and the omicron BA.1, BA.2, BA.2.12.1, and BA.4 or BA.5 subvariants. In Panels B and C, medians (black bars) are shown numerically, and factor differences from other subvariants are indicated; the dashed horizontal line indicates the lower limit of detection for the assay.
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