Transcriptome, connectome and neuromodulation of the primate brain

Cell. 2022 Jun 17;S0092-8674(22)00595-5. doi: 10.1016/j.cell.2022.05.011. Online ahead of print.

Abstract

Single-cell transcriptomic analysis has facilitated cell type identification in the brain and mapping of cell type-specific connectomes, helping to elucidate neural circuits underlying brain functions and to treat brain disorders by neuromodulation. Yet, we lack a consensual definition of neuronal types/subtypes and clear distinction between cause and effect within interconnected networks.