T1 and T2∗ relaxation time in the parcellated myocardium of healthy Taiwanese participants: A single center study

Chih-Chien Tsai; Shu-Hang Ng; Yao-Liang Chen; Yu-Hsiang Juan; Chao-Hung Wang; Gigin Lin; Chih-Wei Chien; Yu-Ching Lin; Yu-Chun Lin; Yu-Chieh Huang; Pei-Ching Huang; Jiun-Jie Wang

doi:10.1016/j.bj.2020.08.013

T1 and T2∗ relaxation time in the parcellated myocardium of healthy Taiwanese participants: A single center study

Biomed J. 2021 Dec;44(6 Suppl 1):S132-S143. doi: 10.1016/j.bj.2020.08.013. Epub 2020 Aug 27.

Authors

Affiliations

¹ Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
² Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
³ Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
⁴ Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Taoyuan, Taoyuan, Taiwan.
⁵ Department of Cardiology and Heart Failure Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
⁶ Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan.
⁷ Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
⁸ Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
⁹ Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Medical Imaging Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address: jwang@mail.cgu.edu.tw.

Abstract

Background: Quantitative maps from cardiac MRI provide objective information for myocardial tissue. The study aimed to report the T1 and T2∗ relaxation time and its relationship with clinical parameters in healthy Taiwanese participants.

Methods: Ninety-three participants were enrolled between 2014 and 2016 (Males/Females: 43/50; age: 49.7 ± 11.3/49.9 ± 10.3). T1 and T2∗ weighted images were obtained by MOLLI recovery and 3D fully flow compensated gradient echo sequences with a 3T MR scanner, respectively. The T1 map of the myocardium was parcellated into 16 partitions from the American Heart Association. The septal part of basal, mid-cavity, and apical view was selected for the T2∗ map. The difference of quantitative map by sex and age groups were evaluated by Student's TTEST and ANOVA, respectively. The relationship between T1, T2∗ map, and clinical parameters, such as ejection fraction, pulse rate, and blood pressures, were evaluated with partial correlation by controlling BMI and age.

Results: Male participants decreased T1 relaxation time in partitions which located in the mid-cavity and apical before 55 years old compared with females (Male/Female: 1143.1.4 ± 72.0-1191.1 ± 37.0/1180.1 ± 54.5-1326.1 ± 113.3 msec, p < 0.01). For female participants, T1 relaxation time was correlated negatively with systolic pressure (p < 0.01) and pulse rate (p < 0.01) before 45 years old. Besides, T1 and T2∗ relaxation time were positively and negatively correlated with ejection fraction and pulse rate after 45 years old in male participants, respectively. Decreased T2∗ relaxation time could be noticed in participants after 45 years old compared with youngers (26.0 ± 6.5/21.9 ± 8.0 msec; 25.2 ± 5.0/21.6 ± 7.2 msec, p < 0.05).

Conclusion: Reference T1 and T2∗ relaxation time from cardiac MRI in healthy Taiwanese participants were provided with sex and age-dependent manners. The relationship between clinical parameters and T1 or T2∗ relaxation time was also established and could be further investigated for its potential application in healthy/sub-healthy participants.

Keywords: Cardiac MRI; Parcellated myocardium; Quantitative mapping; Relaxation time; Taiwanese participants.

MeSH terms

Adult
Female
Healthy Volunteers
Heart / diagnostic imaging*
Heart / physiology*
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Myocardium / pathology
Reproducibility of Results
Ventricular Function, Left