Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity

Clin Cancer Res. 2022 Sep 1;28(17):3636-3638. doi: 10.1158/1078-0432.CCR-22-1255.

Abstract

A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814.

Trial registration: ClinicalTrials.gov NCT04986696 NCT04592887.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell*
  • Cats
  • Radiation Oncology*
  • Radiotherapy Dosage
  • Swine
  • Swine, Miniature

Associated data

  • ClinicalTrials.gov/NCT04986696
  • ClinicalTrials.gov/NCT04592887