RREB1 promotes the development of parafollicular carcinogenesis through the Ras-Raf-1-ELK3 signaling pathway

Nucleosides Nucleotides Nucleic Acids. 2022;41(10):972-981. doi: 10.1080/15257770.2022.2090000. Epub 2022 Jun 23.

Abstract

Thyroid cancer (TC) is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) is derived from parathyroid follicle cells (C cells) secrete calcitonin, accounting for approximately 5-10% of all thyroid cancers. The malignancy is between differentiated and undifferentiated thyroid cancer and undifferentiated thyroid cancer and has a relatively poor prognosis. In MTC tumor cells, RREB1 regulates the differentiation of parathyroid cells via RAS-Raf-1-ELK3 signaling and induce calcitonin secretion. Therefore, it is easy to induce parathyroid parafollicular cells canceration and medullary thyroid carcinoma. Here, we investigated the correlation between RREB1, RAS-Raf-1-ELK3 signaling pathway and medullary thyroid carcinoma with various phases. Our results suggest that RREB1 promotes parafollicular carcinoma through the Ras-Raf1-elk3 signaling pathway, providing a rationale to further investigate the role of RREB1 in parafollicular carcinoma. It provides theoretical guidance for the clinical treatment of medullary thyroid cancer.

Keywords: RREB1; Ras-Raf1-ELK3 signaling pathway; parathyroid parafollicular cells; thyroid carcinoma.

MeSH terms

  • Calcitonin / metabolism
  • Calcitonin / therapeutic use
  • Carcinogenesis
  • Carcinoma, Neuroendocrine* / pathology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Proto-Oncogene Proteins c-ets / metabolism
  • Signal Transduction
  • Thyroid Neoplasms* / drug therapy
  • Thyroid Neoplasms* / metabolism
  • Thyroid Neoplasms* / pathology
  • Transcription Factors

Substances

  • DNA-Binding Proteins
  • Elk3 protein, human
  • Proto-Oncogene Proteins c-ets
  • RREB1 protein, human
  • Transcription Factors
  • Calcitonin

Supplementary concepts

  • Thyroid cancer, medullary