Incidence density and factors associated with peripheral neuropathy among women with breast cancer during taxane-based chemotherapy

Sci Rep. 2022 Jun 23;12(1):10632. doi: 10.1038/s41598-022-14870-y.

Abstract

This work aimed to determine the incidence density of taxane-induced peripheral neuropathy (TIPN) and its risk factors among women with breast cancer. One hundred and forty-one women with breast cancer participated in this cohort study. TIPN symptoms were evaluated with the European Organization for Research and Treatment of Cancer CIPN specific self-report questionnaire (EORTC QOL-CIPN20) at five-time points throughout chemotherapy treatment. Over three months, 125 (89%) and 59 (44.03%) women with breast cancer were identified with sensory and motor neuropathy, respectively. The sensory neuropathy incidence density was 21 per 1000 person-days. The motor neuropathy incidence density was 6 per 1000 person-days. This study discovered a significant link between age and the incidence density of sensory neuropathy (HR = 1.02; 95% CI: 1.01-1.05) as well as motor neuropathy (HR = 1.05; 95% CI: 1.01-1.08). These findings imply that screening may be necessary to detect early TIPN symptoms and provide appropriate rehabilitation programs, particularly for elderly persons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents* / adverse effects
  • Breast Neoplasms* / chemically induced
  • Breast Neoplasms* / complications
  • Breast Neoplasms* / drug therapy
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Male
  • Peripheral Nervous System Diseases* / chemically induced
  • Peripheral Nervous System Diseases* / diagnosis
  • Peripheral Nervous System Diseases* / epidemiology
  • Quality of Life
  • Taxoids

Substances

  • Antineoplastic Agents
  • Taxoids