Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Int J Mol Sci. 2022 Jun 15;23(12):6675. doi: 10.3390/ijms23126675.


Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.

Keywords: alkali treatment; calcium phosphate coating; sintering; surface modification; zirconia.

MeSH terms

  • Calcium Phosphates
  • Coated Materials, Biocompatible* / pharmacology
  • Dental Implants*
  • Osseointegration
  • Phosphates
  • Surface Properties
  • Titanium / pharmacology
  • Zirconium


  • Calcium Phosphates
  • Coated Materials, Biocompatible
  • Dental Implants
  • Phosphates
  • Zirconium
  • Titanium
  • zirconium oxide