Nutrition and Supplementation in Ulcerative Colitis

Nutrients. 2022 Jun 14;14(12):2469. doi: 10.3390/nu14122469.


Ulcerative colitis (UC) belongs to the group of inflammatory bowel diseases (IBD). UC is an incurable, diffuse, and chronic inflammatory process of the colonic mucosa with alternating periods of exacerbation and remission. This review aimed to analyze the scientific research conducted to date to determine what impact different nutritional plans and dietary supplements may have on the course of UC. The latest 98 articles about nutrition and supplementation in ulcerative colitis were used to prepare the work. Certain components in food can greatly influence the course of UC, inducing changes in the composition and function of the gut microbiome. This activity may be an important part of therapy for people with IBD. The Mediterranean diet has shown the most promising results in the treatment of patients with UC due to its high content of biologically active foods. Patients with UC may benefit from the UC Exclusion Diet (UCED); however, it is a new nutritional plan that requires further research. Patents frequently resort to unconventional diets, which, because of their frequent elimination of nutrient-rich foods, can worsen the health and nutritional status of those who follow them. The benefits of omega-3 fatty acids and probiotics supplementation may have additional therapeutic effects; however, the evidence is not unequivocal.

Keywords: FODMAP; Mediterranean diet; SCD; UCED; colitis ulcerosa; diet; supplements; ulcerative colitis.

Publication types

  • Review

MeSH terms

  • Colitis, Ulcerative* / therapy
  • Diet / adverse effects
  • Dietary Supplements
  • Humans
  • Inflammatory Bowel Diseases* / complications
  • Nutritional Status

Grants and funding

This research received no external funding.