Schizophrenia and Inflammation Research: A Bibliometric Analysis

Front Immunol. 2022 Jun 9;13:907851. doi: 10.3389/fimmu.2022.907851. eCollection 2022.


Background: Schizophrenia (SCZ) is a severe psychiatric disorder that involves inflammatory processes. The aim of this study was to explore the field of inflammation-related research in SCZ from a bibliometric perspective.

Methods: Regular and review articles on SCZ- and inflammation-related research were obtained from the Web of Science Core Collection (WOSCC) database from its inception to February 19, 2022. R package "bibliometrix" was used to summarize the main findings, count the occurrences of the top keywords, visualize the collaboration network between countries, and generate a three-field plot. VOSviewer software was applied to conduct both co-authorship and co-occurrence analyses. CiteSpace was used to identify the top references and keywords with the strongest citation burst.

Results: A total of 3,596 publications on SCZ and inflammation were included. Publications were mainly from the USA, China, and Germany. The highest number of publications was found in a list of relevant journals. Apart from "schizophrenia" and "inflammatory", the terms "bipolar disorder," "brain," and "meta-analysis" were also the most frequently used keywords.

Conclusions: This bibliometric study mapped out a fundamental knowledge structure consisting of countries, institutions, authors, journals, and articles in the research field of SCZ and inflammation over the past 30 years. The results provide a comprehensive perspective about the wider landscape of this research area.

Keywords: VOSviewer; bibliometrics; hotspots; inflammation; schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bibliometrics
  • China
  • Humans
  • Inflammation
  • Schizophrenia*
  • Software