Toward harmonization of strategies for investigating lucidity in AD/ADRD: A preliminary research framework

Alzheimers Dement. 2023 Jan;19(1):343-352. doi: 10.1002/alz.12709. Epub 2022 Jun 27.


Episodes of lucidity (ELs) in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD), have garnered increasing attention as an important area of research. Efforts to study lucidity suffer from a lack of clear definitional criteria, inconsistent conceptualization, and diverse approaches to operationalizing features of these events. To advance systematic investigation of ELs in AD/ADRD, there is a need for clarity and precision in labeling event attributes, markers, and specific measurement strategies that enable operational harmonization across distinct approaches to investigating the relatively broad and nascent phenomenon. To that end, we propose a preliminary research framework to guide harmonization of approaches to investigating ELs in AD/ADRD. Our goal is to provide an initial schematic that encourages uniform labeling of operational decisions about ELs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alzheimer Disease*
  • Cognition
  • Dementia*
  • Humans