Biochemical testing to differentiate Cushing's disease from ectopic ACTH syndrome

Amandine Ferriere; Antoine Tabarin

doi:10.1007/s11102-022-01241-z

Biochemical testing to differentiate Cushing's disease from ectopic ACTH syndrome

Pituitary. 2022 Oct;25(5):705-708. doi: 10.1007/s11102-022-01241-z. Epub 2022 Jun 27.

Authors

Amandine Ferriere¹, Antoine Tabarin²

Affiliations

¹ Department of Endocrinology, Diabetes and Nutrition, CHU of Bordeaux and University of Bordeaux, 33604, Pessac, France.
² Department of Endocrinology, Diabetes and Nutrition, CHU of Bordeaux and University of Bordeaux, 33604, Pessac, France. antoine.tabarin@chu-bordeaux.fr.

PMID: 35759056
DOI: 10.1007/s11102-022-01241-z

Abstract

The differential diagnosis of ACTH-dependent Cushing's syndrome is often a diagnostic challenge that has been debated in numerous studies. In this short article, we will discuss the performance and main drawbacks of the biochemical tests used for this diagnosis.

Keywords: CRH test; Cushing’s disease; Desmopressin test; Dexamethasone suppression test; Ectopic ACTH syndrome; Inferior petrosal sinus sampling.

Publication types

Review

MeSH terms

ACTH Syndrome, Ectopic* / diagnosis
Adrenocorticotropic Hormone
Corticotropin-Releasing Hormone
Cushing Syndrome* / diagnosis
Diagnosis, Differential
Humans
Petrosal Sinus Sampling
Pituitary ACTH Hypersecretion* / diagnosis

Substances

Adrenocorticotropic Hormone
Corticotropin-Releasing Hormone