The sensitivity of colorimetric photonic crystal (PC) sensors have been significantly improved with the advancement of deformable structural color materials, structures design, sensing signal analysis methods, and fabrication strategies. In this perspective, the strategies toward high-sensitivity colorimetric PC sensors are discussed, from the perspectives of molecular design, single sensor construction, and multisensor assembly, which include incorporation of flexible polymer chains, construction of strong sensor-analyte interactions, incorporation of more soft materials, construction of stimuli-angle/orientation relationship, design of colorimetric sensors in series, and assembly of colorimetric PC sensors in parallel. Based on these strategies, progress of high-sensitivity colorimetric PC sensors in recent years is summarized, in terms of mechano-sensors and chemo-/biosensors. Specifically, PC based optical-electrical dual-signal sensing devices are included. Finally, the future development and challenges of high-sensitivity colorimetric PC sensors are presented, in regards to deformable properties, optical properties, analysis methods, and fabrication strategies.