Long term oral health related quality of life after TMJ arthrocentesis with hyaluronic acid. A retrospective cohort study

J Craniomaxillofac Surg. 2022 Jul;50(7):583-589. doi: 10.1016/j.jcms.2022.06.004. Epub 2022 Jun 17.


The purpose of the study was to assess the long-term oral health-related quality of life (oQoL) in patients with temporomandibular joint (TMJ) internal derangement (ID) after TMJ arthrocentesis plus hyaluronic acid (HA). Patients were analysed at different follow-up times using an analytical observational design. The Oral Health Impact Profile-14 (OHIP-14) score was evaluated according to age, sex, disc position, presence of degenerative joint disease (DJD), joint pain, maximum mouth opening and follow-up time. A total of 60 participants were enrolled, 88% female, with a mean age of 38 years (SD = 13.48). In an average follow-up of 25.02 months (SD = 5.32), the OHIP-14 total score decreased 8.67 (95% confidence interval [CI]: -11.21 to -6.11) after the intervention (Cohen's d = 1.22; 95% CI = 0.81 to 1.64). All OHIP-14 domain scores decreased (p < 0.05) except for the Functional limitation domain (p = 0.378). The oQoL after the intervention worsened in female patients (p = 0.039) and with a higher level of pain at baseline (p = 0.002). Self-perceived QoL improvement should be considered stable long term after temporomandibular joint arthrocentesis plus HA, regardless of concurrence with DJD or ID subtype. QoL should be used as clinical assessment measure of ID patients, with special attention to those with higher levels of pain.

Keywords: Arthrocentesis; Hyaluronic acid; Internal derangement; Quality of life; Temporomandibular joint disorders.

MeSH terms

  • Adult
  • Arthrocentesis*
  • Female
  • Humans
  • Hyaluronic Acid / therapeutic use
  • Injections, Intra-Articular
  • Male
  • Pain
  • Quality of Life
  • Range of Motion, Articular
  • Retrospective Studies
  • Temporomandibular Joint / surgery
  • Temporomandibular Joint Disorders* / surgery
  • Treatment Outcome


  • Hyaluronic Acid