The humoral response and antibodies against SARS-CoV-2 infection

doi:10.1038/s41590-022-01248-5

Review

. 2022 Jul;23(7):1008-1020.

doi: 10.1038/s41590-022-01248-5. Epub 2022 Jun 27.

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi^#^{1

2

3

4

5

6}, Bo Liu^{7

8

9}, Xinquan Wang^{10

11}, Linqi Zhang^#^{12

13

14

15}

Affiliations

¹ Tsinghua-Peking Center for Life Sciences, Beijing, China. qihai@tsinghua.edu.cn.
² Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
³ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁴ NexVac Research Center, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁵ Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China. qihai@tsinghua.edu.cn.
⁶ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁷ Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁸ Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China.
⁹ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
¹⁰ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.
¹¹ School of Life Sciences, Tsinghua University, Beijing, China.
¹² Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹³ NexVac Research Center, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁴ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁵ Comprehensive AIDS Research Center, Center for Global Health and Infectious Diseases, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.

^# Contributed equally.

PMID: 35761083
DOI: 10.1038/s41590-022-01248-5

Review

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi et al. Nat Immunol. 2022 Jul.

. 2022 Jul;23(7):1008-1020.

doi: 10.1038/s41590-022-01248-5. Epub 2022 Jun 27.

Authors

Hai Qi^#^{1

2

3

4

5

6}, Bo Liu^{7

8

9}, Xinquan Wang^{10

11}, Linqi Zhang^#^{12

13

14

15}

Affiliations

¹ Tsinghua-Peking Center for Life Sciences, Beijing, China. qihai@tsinghua.edu.cn.
² Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
³ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁴ NexVac Research Center, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁵ Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, China. qihai@tsinghua.edu.cn.
⁶ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. qihai@tsinghua.edu.cn.
⁷ Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁸ Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China.
⁹ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
¹⁰ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.
¹¹ School of Life Sciences, Tsinghua University, Beijing, China.
¹² Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹³ NexVac Research Center, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁴ Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.
¹⁵ Comprehensive AIDS Research Center, Center for Global Health and Infectious Diseases, Tsinghua University, Beijing, China. zhanglinqi@tsinghua.edu.cn.

^# Contributed equally.

PMID: 35761083
DOI: 10.1038/s41590-022-01248-5

Abstract

Two and a half years into the COVID-19 pandemic, we have gained many insights into the human antibody response to the causative SARS-CoV-2 virus. In this Review, we summarize key observations of humoral immune responses in people with COVID-19, discuss key features of infection- and vaccine-induced neutralizing antibodies, and consider vaccine designs for inducing antibodies that are broadly protective against different variants of the SARS-CoV-2 virus.

PubMed Disclaimer

Cited by

Plaque Reduction Neutralization Test (PRNT) Accuracy in Evaluating Humoral Immune Response to SARS-CoV-2.
Horbach IS, de Souza Azevedo A, Schwarcz WD, Alves NDS, de Moura Dias B, Setatino BP, da Cruz Moura L, de Souza AF, Denani CB, da Silva SA, Pimentel TG, de Oliveira Silva Ferreira V, Azamor T, Ano Bom APD, da Penha Gomes Gouvea M, Mill JG, Valim V, Polese J, Campi-Azevedo AC, Peruhype-Magalhães V, Teixeira-Carvalho A, Martins-Filho OA, de Lima SMB, de Sousa Junior IP. Horbach IS, et al. Diseases. 2024 Jan 18;12(1):29. doi: 10.3390/diseases12010029. Diseases. 2024. PMID: 38248380 Free PMC article.
Clinical and laboratory considerations: determining an antibody-based composite correlate of risk for reinfection with SARS-CoV-2 or severe COVID-19.
Holdenrieder S, Dos Santos Ferreira CE, Izopet J, Theel ES, Wieser A. Holdenrieder S, et al. Front Public Health. 2023 Dec 28;11:1290402. doi: 10.3389/fpubh.2023.1290402. eCollection 2023. Front Public Health. 2023. PMID: 38222091 Free PMC article.
Development and Validation of a Highly Sensitive Multiplex Immunoassay for SARS-CoV-2 Humoral Response Monitorization: A Study of the Antibody Response in COVID-19 Patients with Different Clinical Profiles during the First and Second Waves in Cadiz, Spain.
Olvera-Collantes L, Moares N, Fernandez-Cisnal R, Muñoz-Miranda JP, Gonzalez-Garcia P, Gabucio A, Freyre-Carrillo C, Jordan-Chaves JD, Trujillo-Soto T, Rodriguez-Martinez MP, Martin-Rubio MI, Escuer E, Rodriguez-Iglesias M, Fernandez-Ponce C, Garcia-Cozar F. Olvera-Collantes L, et al. Microorganisms. 2023 Dec 16;11(12):2997. doi: 10.3390/microorganisms11122997. Microorganisms. 2023. PMID: 38138141 Free PMC article.
Innovation-driven trend shaping COVID-19 vaccine development in China.
Zhang Y, Zhao Y, Liang H, Xu Y, Zhou C, Yao Y, Wang H, Yang X. Zhang Y, et al. Front Med. 2023 Dec;17(6):1096-1116. doi: 10.1007/s11684-023-1034-6. Epub 2023 Dec 16. Front Med. 2023. PMID: 38102402 Review.
Impact of Surge Strain and Pandemic Progression on Prognostication by an Established COVID-19-Specific Severity Score.
Yek C, Wang J, Fintzi J, Mancera AG, Keller MB, Warner S, Kadri SS. Yek C, et al. Crit Care Explor. 2023 Dec 12;5(12):e1021. doi: 10.1097/CCE.0000000000001021. eCollection 2023 Dec. Crit Care Explor. 2023. PMID: 38094088 Free PMC article.

See all "Cited by" articles

References

1. Carvalho, T., Krammer, F. & Iwasaki, A. The first 12 months of COVID-19: a timeline of immunological insights. Nat. Rev. Immunol. 21, 245–256 (2021). - PubMed - PMC - DOI
1. Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H. & Tham, T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol. Head. Neck Surg. 163, 3–11 (2020). - PubMed - DOI
1. da Rosa Mesquita, R. et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wien. Klin. Wochenschr. 133, 377–382 (2021). - PubMed - DOI
1. Wichmann, D. et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann. Intern. Med. 173, 268–277 (2020). - PubMed - DOI
1. Jose, R. J. & Manuel, A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir. Med 8, e46–e47 (2020). - PubMed - DOI

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

HHMI/Howard Hughes Medical Institute/United States

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Medical
- Genetic Alliance
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Carvalho, T., Krammer, F. & Iwasaki, A. The first 12 months of COVID-19: a timeline of immunological insights. Nat. Rev. Immunol. 21, 245–256 (2021). - PubMed - PMC - DOI

[2] Carvalho, T., Krammer, F. & Iwasaki, A. The first 12 months of COVID-19: a timeline of immunological insights. Nat. Rev. Immunol. 21, 245–256 (2021). - PubMed - PMC - DOI

[3] Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H. & Tham, T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol. Head. Neck Surg. 163, 3–11 (2020). - PubMed - DOI

[4] Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H. & Tham, T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol. Head. Neck Surg. 163, 3–11 (2020). - PubMed - DOI

[5] da Rosa Mesquita, R. et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wien. Klin. Wochenschr. 133, 377–382 (2021). - PubMed - DOI

[6] da Rosa Mesquita, R. et al. Clinical manifestations of COVID-19 in the general population: systematic review. Wien. Klin. Wochenschr. 133, 377–382 (2021). - PubMed - DOI

[7] Wichmann, D. et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann. Intern. Med. 173, 268–277 (2020). - PubMed - DOI

[8] Wichmann, D. et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann. Intern. Med. 173, 268–277 (2020). - PubMed - DOI

[9] Jose, R. J. & Manuel, A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir. Med 8, e46–e47 (2020). - PubMed - DOI

[10] Jose, R. J. & Manuel, A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir. Med 8, e46–e47 (2020). - PubMed - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The humoral response and antibodies against SARS-CoV-2 infection

Affiliations

The humoral response and antibodies against SARS-CoV-2 infection

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous