Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis

Scand J Gastroenterol. 1987 Mar;22(2):214-8. doi: 10.3109/00365528708991882.


The familial occurrence of inflammatory bowel disease (IBD) was investigated among 963 patients with ulcerative colitis (UC) diagnosed in 1955-1979 in Stockholm County. For 76 patients who had a relative with IBD a pedigree was drawn. The diagnoses of the diseased relatives were verified. There was a general prevalence of 7.9% for IBD among relatives. In 80% one relative was affected, in most cases a first-degree relative with UC. Sibship was the commonest relationship. No concordance for UC was found among three pairs of monozygotic twins. The prevalence of UC in first-degree relatives was 15 times higher than in non-relatives. The age of onset was significantly lower among patients with a family history for UC; they also had a higher incidence of total colitis. The prevalence of Crohn's disease in first-degree relatives of patients with UC was almost 3.5 times higher than in non-relatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Child
  • Colitis, Ulcerative / genetics*
  • Colonic Diseases, Functional / epidemiology
  • Colonic Diseases, Functional / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Sweden