Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease

Yun-Long Xu; Lin Zhu; Zi-Jun Chen; Xiao-Fei Deng; Pei-Dong Liu; Shan Li; Bing-Chun Lin; Chuan-Zhong Yang; Wei Xu; Kui-Kui Zhou; Ying-Jie Zhu

doi:10.1007/s12264-022-00900-2

Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease

Neurosci Bull. 2022 Nov;38(11):1425-1430. doi: 10.1007/s12264-022-00900-2. Epub 2022 Jun 28.

Authors

Yun-Long Xu^#^{1

2}, Lin Zhu^#³, Zi-Jun Chen^#¹, Xiao-Fei Deng¹, Pei-Dong Liu⁴, Shan Li³, Bing-Chun Lin^{3

5}, Chuan-Zhong Yang³, Wei Xu⁶, Kui-Kui Zhou⁷, Ying-Jie Zhu^{8

9

10

11

12}

Affiliations

¹ Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Department of Neonatology, Shenzhen Maternity & Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, 518055, China.
⁴ The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
⁵ Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
⁶ Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China. freefresh2000@163.com.
⁷ Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China. kk.zhou@siat.ac.cn.
⁸ Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China. yj.zhu1@siat.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. yj.zhu1@siat.ac.cn.
¹⁰ Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, CAS, Shenzhen, 518055, China. yj.zhu1@siat.ac.cn.
¹¹ CAS Center for Excellence in Brain Science and Intelligence Technology, CAS, Shanghai, 200031, China. yj.zhu1@siat.ac.cn.
¹² CAS Key Laboratory of Brain Connectome and Manipulation, BCBDI, Shenzhen Institute of Advanced Technology (SIAT), CAS, Shenzhen, 518055, China. yj.zhu1@siat.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / complications
Animals
Brain-Derived Neurotrophic Factor / metabolism
Disease Models, Animal
Entorhinal Cortex / metabolism
Memory Disorders / etiology
Mice
Thalamus / metabolism

Substances

Brain-Derived Neurotrophic Factor