Inflammatory Responses After Ischemic Stroke

Semin Immunopathol. 2022 Sep;44(5):625-648. doi: 10.1007/s00281-022-00943-7. Epub 2022 Jun 29.


Ischemic stroke generates an immune response that contributes to neuronal loss as well as tissue repair. This is a complex process involving a range of cell types and effector molecules and impacts tissues outside of the CNS. Recent reviews address specific aspects of this response, but several years have passed and important advances have been made since a high-level review has summarized the overall state of the field. The present review examines the initiation of the inflammatory response after ischemic stroke, the complex impacts of leukocytes on patient outcome, and the potential of basic science discoveries to impact the development of therapeutics. The information summarized here is derived from broad PubMed searches and aims to reflect recent research advances in an unbiased manner. We highlight valuable recent discoveries and identify gaps in knowledge that have the potential to advance our understanding of this disease and therapies to improve patient outcomes.

Keywords: Brain; Inflammation; Ischemic stroke; Leukocyte; Neurotoxic; Reparative.

Publication types

  • Review

MeSH terms

  • Humans
  • Inflammation / metabolism
  • Ischemic Stroke* / diagnosis
  • Ischemic Stroke* / etiology
  • Ischemic Stroke* / therapy
  • Leukocytes / metabolism