Breakthrough SARS-CoV-2 infections after COVID-19 immunization

J Investig Med. 2022 Aug;70(6):1429-1432. doi: 10.1136/jim-2021-002131. Epub 2022 Jun 29.


As no vaccines are 100% effective at preventing illness, COVID-19 vaccine breakthrough cases are expected. We here aim to review the most recent literature on COVID-19 vaccine breakthrough infections. SARS-CoV-2 breakthrough infections are, in general, rare. Age may still be a factor in SARS-CoV-2 infections in immunized individuals.

Keywords: COVID-19; viral vaccines.

Publication types

  • Review

MeSH terms

  • COVID-19 Vaccines
  • COVID-19* / prevention & control
  • Humans
  • SARS-CoV-2
  • Vaccination
  • Viral Vaccines*


  • COVID-19 Vaccines
  • Viral Vaccines

Supplementary concepts

  • COVID-19 breakthrough infections