Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story?

Am J Psychiatry. 2022 Jul;179(7):448-450. doi: 10.1176/appi.ajp.20220434.
No abstract available

Keywords: Bupropion; Clinical Drug Studies; Depressive Disorders; Dextromethorphan; Major Depressive Disorder; Pharmacotherapy.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Analgesics, Opioid* / pharmacology
  • Analgesics, Opioid* / therapeutic use
  • Bupropion*
  • Dextromethorphan / pharmacology
  • Dextromethorphan / therapeutic use
  • Excitatory Amino Acid Antagonists / pharmacology
  • Excitatory Amino Acid Antagonists / therapeutic use
  • Humans
  • N-Methylaspartate

Substances

  • Analgesics, Opioid
  • Excitatory Amino Acid Antagonists
  • Bupropion
  • N-Methylaspartate
  • Dextromethorphan