A total of 410 patients with fresh syphilis were examined at a dermato-venereological outpatient centre. With regard to the pathomoprhosis the authors identified psychic disorders (psychogenic and somatogenic) which were characteristic of the periods of the pre-diagnostic, diagnostic, inpatient and outpatient treatment. The patients presented variants of neurotic depression, neurasthenic, astheno-vegetative, hysterical and other syndromes. Suicidal thoughts and attempts were also observed. Characteristics of psychic disorders were considered with regard to sex and age. Therapeutic recommendations are provided.