Therapy for contact lens-related ulcers

Curr Opin Ophthalmol. 2022 Jul 1;33(4):282-289. doi: 10.1097/ICU.0000000000000861.


Purpose of review: The current review covers the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). Although the majority of corneal ulcers are bacterial, fungus and acanthamoeba are substantial contributors in CLMK and are harder to treat due to the lack of commercially available topical medications and low efficacy of available topical therapy.

Recent findings: Topical antimicrobials remain the mainstay of therapy for corneal ulcers. Fluoroquinolones may be used as monotherapy for small, peripheral bacterial ulcers. Antibiotic resistance is a persistent problem. Fungal ulcers are less responsive to topical medications and adjunct oral or intrastromal antifungal medications may be helpful. Acanthamoeba keratitis continues to remain a therapeutic challenge but newer antifungal and antiparasitic agents may be helpful adjuncts. Other novel and innovative therapies are being studied currently and show promise.

Summary: Contact lens-associated microbial keratitis is a significant health issue that can cause vision loss. Treatment remains a challenge but many promising diagnostics and procedures are in the pipeline and offer hope.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / therapeutic use
  • Bacteria
  • Contact Lenses* / adverse effects
  • Corneal Ulcer* / diagnosis
  • Corneal Ulcer* / drug therapy
  • Humans
  • Keratitis* / drug therapy
  • Ulcer / drug therapy


  • Antifungal Agents