EVs predict the outcomes in patients with acute myocardial infarction

Tissue Cell. 2022 Aug;77:101857. doi: 10.1016/j.tice.2022.101857. Epub 2022 Jun 20.

Abstract

Acute myocardial infarction (AMI) is a condition with myocardial necrosis caused by an unstable ischemic syndrome. AMI is the leading cause of disability and death around the world. Extracellular vesicles (EVs) are small-sized fragments of phospholipids produced by the outward budding of the cell membrane of different types of cells (red blood cells, endothelial cells, platelets, and leukocytes). EVs are released in healthy individuals and patients with various diseases and health conditions. EVs can be detected in all biological fluids such as plasma, urine, and CSF. In this article, we attempt to answer the question, "Can circulating extracellular vesicles be used as potential biomarkers in AMI?".

Keywords: Acute myocardial infarction; Biomarker; Extracellular vesicles; Microvesicles.

Publication types

  • Review

MeSH terms

  • Biomarkers / metabolism
  • Blood Platelets / metabolism
  • Endothelial Cells / metabolism
  • Extracellular Vesicles* / metabolism
  • Humans
  • Myocardial Infarction*

Substances

  • Biomarkers