Versatile signaling mechanisms of inositol pyrophosphates

Abstract

Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules, the different modes of action they can access, and a somewhat limited chemical and analytical toolset. Herein, we summarize the most recent mechanistic insights into PP-InsP signaling, which illustrate our progress in connecting mechanism and function of PP-InsPs.

Keywords: 5PP-InsP(5); Cell signaling; Chemical tools; IP6K; Inositol phosphate; Inositol pyrophosphate; InsP(8); PPIP5K; Protein ligand interaction; Protein pyrophosphorylation; SPX domain.