Cryoballoon Ablation versus Radiofrequency Ablation in Patients with Persistent Atrial Fibrillation (CRRF-PeAF): Protocol for a Prospective, Multicenter, Randomized, Controlled Study

Koji Miyamoto; Koshiro Kanaoka; Masue Yoh; Hiroki Takahashi; Jun Kishihara; Masahiro Ishikura; Yasuhiro Sasaki; Hiroshi Fukunaga; Takahiko Nagase; So Asano; Shingo Mizuno; Shintaro Yamagami; Yoshinao Yazaki; Takahiro Kusume; Yasuyuki Takada; Kenji Yodogawa; Wataru Shimizu; Takatoshi Shigeta; Yuichiro Sagawa; Yuko Inoue; Satoshi Nagase; Takeshi Aiba; Masahiko Takagi; Hidehira Fukaya; Atsushi Kobori; Junichi Nitta; Masato Murakami; Suguru Nishiuchi; Kazuhiro Satomi; Naoya Kataoka; Yu-Ki Iwasaki; Keiichi Ashikaga; Yasuteru Yamauchi; Kengo Kusano

doi:10.1016/j.ijcha.2022.101074

Cryoballoon Ablation versus Radiofrequency Ablation in Patients with Persistent Atrial Fibrillation (CRRF-PeAF): Protocol for a Prospective, Multicenter, Randomized, Controlled Study

Int J Cardiol Heart Vasc. 2022 Jun 25:41:101074. doi: 10.1016/j.ijcha.2022.101074. eCollection 2022 Aug.

Authors

Koji Miyamoto¹, Koshiro Kanaoka², Masue Yoh³, Hiroki Takahashi³, Jun Kishihara⁴, Masahiro Ishikura⁵, Yasuhiro Sasaki⁵, Hiroshi Fukunaga⁶, Takahiko Nagase⁶, So Asano⁶, Shingo Mizuno⁷, Shintaro Yamagami⁸, Yoshinao Yazaki⁹, Takahiro Kusume⁹, Yasuyuki Takada⁹, Kenji Yodogawa¹⁰, Wataru Shimizu¹⁰, Takatoshi Shigeta¹¹, Yuichiro Sagawa¹¹, Yuko Inoue¹, Satoshi Nagase¹, Takeshi Aiba¹, Masahiko Takagi³, Hidehira Fukaya⁴, Atsushi Kobori⁵, Junichi Nitta⁶, Masato Murakami⁷, Suguru Nishiuchi⁸, Kazuhiro Satomi⁹, Naoya Kataoka¹², Yu-Ki Iwasaki¹⁰, Keiichi Ashikaga¹³, Yasuteru Yamauchi¹¹, Kengo Kusano¹

Affiliations

¹ Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
² Department of Medical and Health Information Management, Open Innovation Center, National Cerebral and Cardiovascular Center, Suita, Japan.
³ Department of Medicine II, Kansai Medical University, Moriguchi, Japan.
⁴ Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
⁵ Department of Cardiology, Kobe City Medical Center General Hospital, Kobe, Japan.
⁶ Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
⁷ Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan.
⁸ Department of Cardiology, Tenri Hospital, Tenri, Japan.
⁹ Department of Cardiovascular Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
¹⁰ Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
¹¹ Department of Cardiology, Japan Red Cross Yokohama City Bay Hospital, Yokohama, Japan.
¹² Second Department of Internal Medicine,University of Toyama, Toyama, Japan.
¹³ Department of Cardiovascular Medicine, Miyazaki Medical Association Hospital, Miyazaki, Japan.

No abstract available

Keywords: AAD, antiarrhythmic drug; AE, adverse event; AF, atrial fibrillation; AT, atrial tachyarrhythmias; BP, blanking period; CA, catheter ablation; CB, cryoballoon; CF, contact force; CRB, Certified Review Board; CRF, Case Report Form; Catheter ablation; Cryoballoon ablation; DSMB, Data and Safety Monitoring Board; LA, left atrium; LAD, left atrial dimension; PAF, paroxysmal atrial fibrillation; PN, phrenic nerve; PV, pulmonary vein; PVI, pulmonary vein isolation; PeAF, Persistent atrial fibrillation; Persistent Atrial fibrillation; QoL, quality of life; RF, radiofrequency; Radiofrequency ablation; jRCT, Japan Registry of Clinical Trials.