Type-1 Grade 2 Multi-Focal Gastric Neuroendocrine Tumors Secondary to Chronic Autoimmune Gastritis

Ziqi Yu; Aiyao Wang; Chong Hu; Tao Yu; Jianyong Chen

doi:10.3389/fmed.2022.856125

Type-1 Grade 2 Multi-Focal Gastric Neuroendocrine Tumors Secondary to Chronic Autoimmune Gastritis

Front Med (Lausanne). 2022 Jun 17:9:856125. doi: 10.3389/fmed.2022.856125. eCollection 2022.

Authors

Ziqi Yu¹, Aiyao Wang², Chong Hu², Tao Yu², Jianyong Chen²

Affiliations

¹ Munich Medical Research School, Ludwig Maximilian University (LMU) of Munich, Munich, Germany.
² Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang Medical College, Jiangxi Provincial People's Hospital, Nanchang, China.

Abstract

Background: Chronic autoimmune gastritis (CAG) refers to chronic atrophic gastritis due to autoimmunity. Loss of gastric glands in CAG results in hypergastrinemia and achlorhydria leading to Vitamin B₁₂ deficiency and hyperplasia of G cells and enterochromaffin-like (ECL) cells. Vitamin B₁₂ deficiency could cause pernicious anemia and subacute combined degeneration, while G cells and ECL cells hyperplasia might develop gastric neuroendocrine tumor (G-NET).

Case presentation: A 35-year-old Chinese female presented with multi-focal type-1 Grade 2 (G2) NETs with a 14-year history of pernicious anemia and subacute combined degeneration.

Conclusion: Here, we report a rare case of a Chinese patient presenting G-NET combined with pernicious anemia and subacute combined degeneration, which are secondary to chronic autoimmune gastritis. This case also illustrates the importance of routine gastroscopy in patients with Vitamin B₁₂ deficiency.

Keywords: ECL cell; G cell hyperplasia; atrophic gastritis; chronic autoimmune gastritis; gastric neuroendocrine tumors; type-1 gastric carcinoid.

Publication types

Case Reports