Neural Correlates of Optimal Deep Brain Stimulation for Cervical Dystonia

Ann Neurol. 2022 Sep;92(3):418-424. doi: 10.1002/ana.26450. Epub 2022 Jul 28.


A total of 15 individuals with cervical dystonia and good outcome after pallidal deep brain stimulation underwent resting-state functional magnetic resonance imaging under three conditions: stimulation using a priori clinically determined optimal settings (ON-Op), non-optimal settings (ON-NOp), and stimulation off (OFF). ON-Op > OFF and ON-Op > ON-NOp were both associated with significant deactivation within sensorimotor cortex (changes not seen with ON-NOp > OFF). Brain responses to stimulation were related to individual long-term clinical improvement (R = 0.73, R2 = 0.53, p = 0.001). The relationship was consistent when this model included four additional patients with generalized or truncal dystonia. These findings highlight the potential for immediate imaging-based biomarkers of clinical efficacy. ANN NEUROL 2022;92:418-424.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain
  • Deep Brain Stimulation* / methods
  • Globus Pallidus / physiology
  • Humans
  • Torticollis* / diagnostic imaging
  • Torticollis* / therapy
  • Treatment Outcome