A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression

Soudeh Ghafouri-Fard; Tayyebeh Khoshbakht; Bashdar Mahmud Hussen; Mohammad Taheri; Mohammad Samadian

doi:10.1186/s12935-022-02644-5

A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression

Cancer Cell Int. 2022 Jul 5;22(1):225. doi: 10.1186/s12935-022-02644-5.

Authors

Soudeh Ghafouri-Fard¹, Tayyebeh Khoshbakht², Bashdar Mahmud Hussen^{3

4}, Mohammad Taheri^{5

6}, Mohammad Samadian⁷

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
⁴ Center of Research and Strategic Studies, Lebanese French University, Kurdistan Region, Erbil, Iraq.
⁵ Institute of Human Genetics, Jena University Hospital, Jena, Germany. mohammad.taheri@uni-jena.de.
⁶ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad.taheri@uni-jena.de.
⁷ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mdsamadian@gmail.com.

Abstract

Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR-193a-5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR-340-5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis.

Keywords: Cancer; MCM3AP-AS1; lncRNA.

Publication types

Review