Hypnobiome: A New, Potential Frontier of Hypnotherapy in the Treatment of Irritable Bowel Syndrome-A Narrative Review of the Literature

Int J Clin Exp Hypn. 2022 Jul-Sep;70(3):286-299. doi: 10.1080/00207144.2022.2094269. Epub 2022 Jul 6.


Increasing evidence suggests that the gut-brain axis may play a key role in health and disease via a bidirectional communication network involving neural and immunoendocrine pathways. This complex interplay deeply influences both gut microbiota and brain behavior. Pathobiome or gut dysbiosis is relevant for the pathogenesis of functional gastrointestinal disorders, such as IBS, chronic pain syndromes, and neurological and mental disorders. As a consequence, targeting the gut microbiota is emerging as a novel, effective therapeutic perspective. Among many treatment options, psychological interventions, including hypnosis, have been used to target the so-called psychobiome and its hypnotic analogue, i.e., hypnobiome, referring to their potential efficacy to modulate the mind-gut axis in IBS patients. A narrative review of the recent literature is provided and circumstantial evidence suggests that hypnobiome may represent a new promising frontier of hypnotherapy.

Keywords: Gut-brain-axis; IBS; hypnobiome; hypnotherapy; mind-gut axis.

Publication types

  • Review

MeSH terms

  • Brain / metabolism
  • Humans
  • Hypnosis*
  • Irritable Bowel Syndrome* / therapy