The role of phosphoinositide 3-kinases in immune-inflammatory responses: potential therapeutic targets for abdominal aortic aneurysm

Cell Cycle. 2022 Nov;21(22):2339-2364. doi: 10.1080/15384101.2022.2094577. Epub 2022 Jul 6.

Abstract

The pathogenesis of abdominal aortic aneurysm (AAA) includes inflammatory responses, matrix metalloproteinases (MMPs) degradation, VSMC apoptosis, oxidative stress, and angiogenesis, among which the inflammatory response plays a key role. At present, surgery is the only curing treatment, and no effective drug can delay AAA progression in clinical practice. Therefore, searching for a signaling pathway related to the immune-inflammatory response is an essential direction for developing drugs targeting AAA. Recent studies have confirmed that the PI3K family plays an important role in many inflammatory diseases and is involved in regulating various cellular functions, especially in the immune-inflammatory response. This review focuses on the role of each isoform of PI3K in each stage of AAA immune-inflammatory response, making available explorations for a deeper understanding of the mechanism of inflammation and immune response during the formation and development of AAA.

Keywords: Abdominal aortic aneurysm; inflammation; phosphoinositide 3-kinases.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aortic Aneurysm, Abdominal* / drug therapy
  • Aortic Aneurysm, Abdominal* / metabolism
  • Disease Models, Animal
  • Humans
  • Immunity
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols

Substances

  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols

Grant support

This study is supported by the National Natural Science Foundation of China [No. 81873525 and 82070491].