Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive

J Cosmet Dermatol. 2023 Feb;22(2):517-528. doi: 10.1111/jocd.15215. Epub 2022 Aug 9.


Background: Actually, the use of chemical peels in cosmetics and dermatology continues to grow due to their versatility, clinical endpoint-directed predictability, and favorable risk profile in comparison to lasers. The chemical peel is a generally safe method for treatment of some skin disorders and to refresh and rejuvenate the skin. The major challenge of chemical peels is the tolerability, that is because of sensitive skin which is one of the most common skin disorders.

Aim: The aim of this study was to evaluate the effectiveness of the new Miamo Renewal Peel Serum formulated with a pool of new generation acids (ELPA25™) on sensitive skin with respect to mandelic acid serum only and with respect to placebo comparison.

Materials and methods: The "in vivo" study following the half-face experimental protocol active versus placebo involved 30 healthy Caucasian female volunteers between 25 and 64 years, with sensitive skin, who were divided into two different groups. ELPA25™ serum was applied in one group three times a week for 8 weeks. The other group, with the same protocol, applied an active serum containing mandelic acid, as control, versus placebo. In particular, skin moisturizing, skin viscoelastic properties, skin surface smoothness, wrinkle reduction, and stratum corneum renewal were evaluated.

Results: Renewal Peel Serum was very well tolerated from sensitive skin. A significant decrease in skin roughness and wrinkle breadth, and an improvement in firmness and in skin elasticity, was observed after 2 months of treatment with respect both to mandelic acid serum and to placebo comparison.

Conclusions: Scientific protocol using self-controlled study methodology and noninvasive skin bioengineering techniques with adequate statistical methods were able to evaluate both the safety and the efficacy of the new Miamo Renewal Peel Serum. This study highlighted that the Miamo Renewal Peel Serum formulated with a patent-pending mixture of new generation acids (ELPA25™) exerts many beneficial effects and it can be successfully employed for sensitive skin.

Keywords: chemical peeling; lactobionic acid; mandelic acid; sensitive skin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Chemexfoliation* / adverse effects
  • Chemexfoliation* / methods
  • Female
  • Humans
  • Mandelic Acids / adverse effects
  • Skin
  • Skin Aging*
  • Skin Diseases* / chemically induced
  • Treatment Outcome


  • mandelic acid
  • Mandelic Acids