Objective: This study aimed to determine the value of arterial spin labeling (ASL) perfusion imaging in assessing the early efficacy of chemoradiotherapy for nasopharyngeal carcinoma (NPC).
Methods: Fifty-five patients with locoregionally advanced NPC underwent conventional 3.0-T magnetic resonance imaging (MRI) and ASL before and after chemoradiotherapy (prescribed dose reached 40 Gy). Based on the response evaluation criteria for solid tumors (RECIST 1.1), the patients were divided into the partial response and stable disease groups. MRI re-examination was performed one month after chemoradiotherapy completion, and patients were divided into residual and non-residual groups. We investigated inter-group differences in ASL-based tumor blood flow (TBF) parameters (pre-treatment tumor blood flow, post-treatment tumor blood flow, and changes in tumor blood flow, i.e., Pre-TBF, Post-TBF, ΔTBF), correlation between TBF parameters and tumor atrophy rate, and value of TBF parameters in predicting sensitivity to chemoradiotherapy.
Results: There were differences in Pre-TBF, Post-TBF, and ΔTBF between the partial response and stable disease groups (p < 0.01). There were also differences in Pre-TBF and ΔTBF between the residual and non-residual groups (p < 0.01). Pre-TBF and ΔTBF were significantly correlated with the tumor atrophy rate; the correlation coefficients were 0.677 and 0.567, respectively (p < 0.01). Pre-TBF had high diagnostic efficacies in predicting sensitivity to chemoradiotherapy and residual tumors, with areas under the curve of 0.845 and 0.831, respectively.
Conclusion: ASL permits a noninvasive approach to predicting the early efficacy of chemoradiotherapy for NPC.
Keywords: Arterial spin labeling; Chemoradiotherapy; Magnetic resonance imaging; Nasopharyngeal carcinoma.
© 2022. The Author(s).