Development of children born after in vitro maturation with a prematuration step versus natural conception: a prospective cohort study

J Assist Reprod Genet. 2022 Aug;39(8):1959-1965. doi: 10.1007/s10815-022-02559-0. Epub 2022 Jul 7.


Purpose: IVM preceded by a prematuration step (capacitation [CAPA]-IVM) improves the acquisition of oocyte developmental competence and can enhance embryo quality. There is currently no follow-up data on babies born from CAPA-IVM. This study investigated developmental outcomes in children born after CAPA-IVM versus natural conception.

Methods: This prospective cohort study was conducted at a fertility clinic in Vietnam in August/September 2019. Children born after CAPA-IVM were propensity score-matched with those born after natural conception. All parents were asked to complete the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires.

Results: A total of 46 parents (23 in each group) of 55 babies (31 CAPA-IVM and 24 natural conception) were included in the study. Baseline characteristics, including mother's age and body mass index, gestational age at delivery, and birth weight, were comparable. The mean age of children at the end of follow-up was 15 months. The overall proportion of children with any abnormal ASQ-3 score was 6.5% in the CAPA-IVM group and 20.8% in the natural conception group (p = 0.24). The proportion of children with a developmental red flag did not differ significantly between the CAPA-IVM and natural conception groups (9.7% vs. 4.2%; p = 0.80).

Conclusions: The use of CAPA-IVM did not have any significant impact on childhood physical and mental development compared with children born as a result of natural conception.

Keywords: ASQ-3; Capacitation; Childhood development; In vitro fertilization; In vitro maturation; Red Flag sign.

MeSH terms

  • Fertilization in Vitro
  • Humans
  • In Vitro Oocyte Maturation Techniques*
  • Oocytes*
  • Oogenesis
  • Prospective Studies