Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains

Biochem Biophys Res Commun. 1987 Apr 29;144(2):1084-9. doi: 10.1016/s0006-291x(87)80075-x.

Abstract

1,2,3,4-Tetrahydroisoquinoline (TIQ) and 2-methyl-1,2,3,4-tetrahydroquinoline (2-Me-TQ) were identified for the first time by gas chromatography-mass spectrometry in the parkinsonian and normal human brains. TIQ, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was markedly increased in the parkinsonian brain and could be an endogenous neurotoxin to induce Parkinson's disease.

MeSH terms

  • Autopsy
  • Brain / pathology
  • Brain Chemistry*
  • Gas Chromatography-Mass Spectrometry / methods
  • Humans
  • Isoquinolines / analysis*
  • Parkinson Disease / metabolism*
  • Quinolines / analysis*
  • Reference Values
  • Tetrahydroisoquinolines*

Substances

  • Isoquinolines
  • Quinolines
  • Tetrahydroisoquinolines
  • 2-methyl-1,2,3,4-tetrahydroquinoline
  • 1,2,3,4-tetrahydroisoquinoline