Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Cell. 2022 Jul 7;185(14):2401-2421. doi: 10.1016/j.cell.2022.06.003.


Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unanswered questions in the ferroptosis field are highlighted. The next decade promises to yield further breakthroughs in the mechanisms governing ferroptosis and additional ways of harnessing ferroptosis for therapeutic benefit.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Death
  • Ferroptosis*
  • Iron / metabolism
  • Lipid Peroxidation
  • Reactive Oxygen Species / metabolism


  • Reactive Oxygen Species
  • Iron