Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease

Int J Mol Sci. 2022 Jun 22;23(13):6950. doi: 10.3390/ijms23136950.


Garlic, Allium sativum, has long been utilized for a number of medicinal purposes around the world, and its medical benefits have been well documented. The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically. Garlic and garlic extracts, especially aged garlic extracts (AGEs), are rich in bioactive compounds, with potent anti-inflammatory, antioxidant and neuroprotective activities. In light of these effects, garlic and its components have been examined in experimental models of Alzheimer's disease (AD), the most common form of dementia without therapy, and a growing health concern in aging societies. With the aim of offering an updated overview, this paper reviews the chemical composition, metabolism and bioavailability of garlic bioactive compounds. In addition, it provides an overview of signaling mechanisms triggered by garlic derivatives, with a focus on allicin and AGE, to improve learning and memory.

Keywords: Alzheimer’s disease; NLRP3 inflammasome; garlic extracts; inflammation; mechanism of action; oxidative damage.

Publication types

  • Review

MeSH terms

  • Aged
  • Alzheimer Disease* / drug therapy
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Biological Products*
  • Disulfides
  • Garlic* / chemistry
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Sulfinic Acids / chemistry
  • Sulfinic Acids / pharmacology
  • Sulfinic Acids / therapeutic use


  • Antioxidants
  • Biological Products
  • Disulfides
  • Plant Extracts
  • Sulfinic Acids
  • allicin

Grants and funding

This research was funded by University of Ferrara.