Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Sensors (Basel). 2022 Jun 23;22(13):4758. doi: 10.3390/s22134758.


Covalent organic frameworks (COFs) are defined as crystalline organic polymers with programmable topological architectures using properly predesigned building blocks precursors. Since the development of the first COF in 2005, many works are emerging using this kind of material for different applications, such as the development of electrochemical sensors and biosensors. COF shows superb characteristics, such as tuneable pore size and structure, permanent porosity, high surface area, thermal stability, and low density. Apart from these special properties, COF's electrochemical behaviour can be modulated using electroactive building blocks. Furthermore, the great variety of functional groups that can be inserted in their structures makes them interesting materials to be conjugated with biological recognition elements, such as antibodies, enzymes, DNA probe, aptamer, etc. Moreover, the possibility of linking them with other special nanomaterials opens a wide range of possibilities to develop new electrochemical sensors and biosensors.

Keywords: COF; electrochemical biosensors; electrochemical sensors.

Publication types

  • Review

MeSH terms

  • Biosensing Techniques*
  • Metal-Organic Frameworks* / chemistry
  • Polymers / chemistry
  • Porosity


  • Metal-Organic Frameworks
  • Polymers