Tools for mammalian glycoscience research

Matthew E Griffin; Linda C Hsieh-Wilson

doi:10.1016/j.cell.2022.06.016

Tools for mammalian glycoscience research

Cell. 2022 Jul 21;185(15):2657-2677. doi: 10.1016/j.cell.2022.06.016. Epub 2022 Jul 8.

Authors

Matthew E Griffin¹, Linda C Hsieh-Wilson²

Affiliations

¹ Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Microbiology and Immunology, Scripps Research, La Jolla, CA 92037, USA.
² Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: lhw@caltech.edu.

Abstract

Cellular carbohydrates or glycans are critical mediators of biological function. Their remarkably diverse structures and varied activities present exciting opportunities for understanding many areas of biology. In this primer, we discuss key methods and recent breakthrough technologies for identifying, monitoring, and manipulating glycans in mammalian systems.

Keywords: carbohydrates; glycans; glycobiology; mammalian biology.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbohydrates*
Mammals
Polysaccharides* / chemistry

Substances

Carbohydrates
Polysaccharides

Abstract

Publication types

MeSH terms

Substances

Grants and funding