Views on high-fat diet linked insulin resistance

Priscilla Daniel; Madhan Krishnan; Monisha Prasad; Shyamaladevi Babu; T M Vijayalakshmi

doi:10.6026/97320630018050

Views on high-fat diet linked insulin resistance

Bioinformation. 2022 Jan 31;18(1):50-52. doi: 10.6026/97320630018050. eCollection 2022.

Authors

Priscilla Daniel¹, Madhan Krishnan^{2

3}, Monisha Prasad³, Shyamaladevi Babu³, T M Vijayalakshmi¹

Affiliations

¹ Department of Medical Biochemistry, Dr. A.L.M PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India.
² Department of Biochemistry, Vels Medical college & Hospital, Vels Institute of Science Technology & Advance Studies (VISTAS), Chennai, Tamilnadu, India.
³ Department of Biochemistry, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India.

Abstract

Insulin resistance is linked to impaired cell metabolism and survival in the peripheral tissues, as well as increased oxidative stress and activated inflammatory responses. Chronic High fat diet insulin resistant to exposure results in liver damage, impaired glucose homeostasis, hyperinsulinemia, late pancreatic-cell failure to generate insulin due to cell exhaustion, and subsequent hyperglycaemia, all of which are hallmarks of Type 2 Diabetes Mellitus (T2DM). Therefore, it is of intrest to document a short review on the impact of a high-fat diet with insulin resistance.

Keywords: Diabetes; high-fat diet; insulin resistance.