Denosumab Therapy in Cherubism

Cleft Palate Craniofac J. 2023 Dec;60(12):1665-1673. doi: 10.1177/10556656221113891. Epub 2022 Jul 12.


Cherubism is a rare disorder characterized by proliferative fibro-osseous lesions that result in bilateral bony hyperplasia of the face. Management varies based on symptom severity and includes longitudinal follow-up, pharmacotherapy, and/or surgical debulking. Off-label treatment with denosumab, a human monoclonal antibody that binds RANKL and inhibits osteoclast function to reduce bone resorption, can be beneficial in suppressing the proliferation of bone to minimize the need for surgery and to control postoperative reproliferation. Close follow-up is needed to maintain appropriate electrolyte levels. The present case demonstrates the achievement of symptomatic control with denosumab in a child with severe refractory cherubism.

Keywords: bone regeneration; craniofacial growth; craniofacial morphology; facial growth; mandible; maxilla; pediatrics.

Publication types

  • Case Reports

MeSH terms

  • Cherubism* / drug therapy
  • Cherubism* / surgery
  • Child
  • Denosumab / therapeutic use
  • Humans
  • Mandible / surgery
  • Maxilla / surgery


  • Denosumab