[Analysis of inhalation allergen of patients with allergic rhinitis in Shenzhen]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jun;36(6):467-472. doi: 10.13201/j.issn.2096-7993.2022.06.012.
[Article in Chinese]

Abstract
in English, Chinese

Objective:To analyzed allergens and screen for common airborne allergens in patients with allergic rhinitis （AR） in Shenzhen, and identified the distribution pattern of allergens in this region. We aimed to provide scientific and feasible statistical and clinical basis for prevention and treatment of allergenic rhinitis. Methods:For 3351 suspected cases of allergenic rhinitis, 18 kinds of airborne allergen serum-specific IgE were determined using a detection system of BioSciTec GmbH company, and statistical analysis was carried out according to sex, age, severity and seasonal allergen. Results:A total of 3,351 cases with allergic rhinitis were positive for airborne allergens. The top five inhalation allergens were Blomia tropicalis （2231, 66.6%）, Dermatophagoides pterronyssinus （2212, 66.0%）, Dermatophagoides farinae （1986, 59.3%）, Cockroach （967, 28.9%）, and Short ragweed （844, 25.2%）. For the severity of the allergen, Dermatophagoides pterronyssinus ≥ level 3 accounted for 41.3% （1385/3351 cases） and Dermatophagoides farinae ≥level 3 accounted for 40.6% （1360/3351 cases）. Blomia tropicalis were classified as level 2, and other allergens were mainly classified as level 1 or 2. The detection rate among different age groups and gender is significantly different. Conclusion:The main airborne allergens in Shenzhen were Blomia tropicalis, Dermatophagoides pterronyssinus, Dermatophagoides farinae, Cockroach, as well as Short ragweed. The distribution of allergens was affected by sex, age and season.

目的：通过对深圳地区变应性鼻炎（AR）患者的变应原进行检测和分析，筛查深圳地区常见吸入性变应原，绘制深圳地区AR患者的变应原分布图谱，为科学、合理地预防和治疗AR提供依据。 方法：对3351例AR患者采用BioSciTec GmbH公司的检测系统，对18种吸入性变应原进行血清特异性IgE检测，测定致敏变应原，并按性别、年龄、严重程度以及季节性变应原等进行统计学分析。 结果：3351例AR患者中，最常见的前5种吸入性变应原依次为热带无爪螨2231例（66.6%），户尘螨2212例（66.0%），粉尘螨1986例（59.3%），蟑螂967例（28.9%），矮豚草844例（25.2%）。变应原严重程度分布中，户尘螨≥3级的占41.3%（1385/3351），粉尘螨≥3级的占40.6%（1360/3351），热带无爪螨以2级为主，其他变应原以1、2级为主。不同年龄段、不同性别变应原的检出率差异有统计学意义（P<0.05和P<0.01）。 结论：深圳地区主要的吸入性变应原为热带无爪螨、户尘螨、粉尘螨、蟑螂及矮豚草。变应原的分布与性别、年龄、月份有一定相关性。.

Keywords: airborne allergen; rhinitis, allergic; specific IgE.

MeSH terms

  • Allergens / analysis
  • Animals
  • Cockroaches*
  • Humans
  • Immunoglobulin E
  • Rhinitis*
  • Rhinitis, Allergic*
  • Skin Tests

Substances

  • Allergens
  • Immunoglobulin E

Grants and funding

深圳市“医疗卫生三名工程”项目资助(No：SZSM202003005)