NEK7: a new target for the treatment of multiple tumors and chronic inflammatory diseases

Inflammopharmacology. 2022 Aug;30(4):1179-1187. doi: 10.1007/s10787-022-01026-7. Epub 2022 Jul 13.


NIMA-related kinase 7 (NEK7) is a serine/threonine kinase, which is the smallest one in mammalian NEK family. At present, many studies have reported that NEK7 has a physiological role in regulating the cell cycle and promoting the mitotic process of cells. In recent years, an increasing number of studies have proposed that NEK7 is involved in the activation of the NLRP3 inflammasome. Under normal conditions, NEK7 is in a low activity state, while under pathological conditions, NEK7 is abnormally expressed and therefore plays a key role in the progression of multiple tumors and chronic inflammatory diseases. This review will concentrate on the mechanism of NEK7 participates in the process of mitosis and regulates the activation of NLRP3 inflammasome, the aberrant expression of NEK7 in a variety of tumors and chronic inflammatory diseases, and some potential inhibitors, which may provide some new ideas for the treatment of diverse tumors and chronic inflammatory diseases associated with NEK7.

Keywords: Chronic inflammatory diseases; Mitosis; NEK7; NLRP3 inflammasome; Tumors.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammasomes* / metabolism
  • Mammals / metabolism
  • NIMA-Related Kinases / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neoplasms* / drug therapy
  • Protein Serine-Threonine Kinases


  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NEK7 protein, human
  • NIMA-Related Kinases
  • Protein Serine-Threonine Kinases