Radiological features of human papillomavirus-related multiphenotypic sinonasal carcinoma: systematic review and case series

Neuroradiology. 2022 Oct;64(10):2049-2058. doi: 10.1007/s00234-022-03009-5. Epub 2022 Jul 14.


Purpose: To comprehensively summarize the radiological characteristics of human papillomavirus (HPV)-related multiphenotypic sinonasal carcinomas (HMSCs).

Methods: We reviewed the findings for patients with HMSCs who underwent computed tomography (CT) and/or magnetic resonance imaging (MRI) and included nine cases from nine publications that were identified through a systematic review and three cases from our institution. Two board-certified radiologists reviewed and evaluated the radiological images.

Results: The locations in almost all cases included the nasal cavity (11/12, 91.7%). The involved paranasal sinuses included the ethmoid sinus (6/12, 50.0%) and maxillary sinus (3/12, 25.0%). The mean long diameter of the tumors was 46.3 mm. The margins in 91.7% (11/12) of the cases were well-defined and smooth. Heterogeneous enhancement on contrast-enhanced CT, heterogeneous high signal intensities on T2-weighted images and heterogeneous enhancement on gadolinium-enhanced T1-weighted images were noted in 2/2, 5/5, and 8/8 cases, respectively. Mean apparent diffusion coefficient values in two cases of our institution were 1.17 and 1.09 × 10-3 mm2/s. Compressive changes in the surrounding structures were common (75%, 9/12). Few cases showed intraorbital or intracranial extension. None of the cases showed a perineural spread, neck lymph node metastasis, or remote lesions.

Conclusions: We summarized the CT and MRI findings of HMSCs. Knowledge of such characteristics is expected to facilitate prompt diagnosis and appropriate management.

Keywords: Computed tomography; Human papillomavirus-related multiphenotypic sinonasal carcinoma; Magnetic resonance imaging; Systematic review.

Publication types

  • Systematic Review

MeSH terms

  • Alphapapillomavirus*
  • Carcinoma*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Nasal Cavity / pathology
  • Papillomaviridae
  • Tomography, X-Ray Computed / methods