Potential impacts to antibiotics use around the dry period if selective dry cow therapy is adopted by dairy herds: An example of the western US

Abstract

Mastitis is a prevalent and expensive disease in dairy herds worldwide. Blanket dry cow therapy (BDCT), in which all quarters of all cows are infused with antimicrobials at the dry-off, is a cornerstone for mastitis control in many countries. An alternative approach is the use of selective dry cow therapy (SDCT), in which only cows with high risk for intramammary infection (IMI) at dry-off receive antimicrobials. Our objectives in this cross-sectional study were to estimate the potential reduction in the use of antimicrobials if SDCT was adopted in the US by using cow-level dairy herd data and to describe the factors associated with cows being classified as high-risk for an IMI at dry-off. Besides, we aimed to describe the seasonality in IMI at dry-off. We used cow-level somatic cell score (SCS) test-day data from herds in the western US (DHIA, Dairy Herd Improvement Association, AgriTech, Visalia, CA) to create five scenarios to classify cows as high risk for IMI at dry-off. Associations between cow-level data and state were also used in logistic regression models. We also calculated the average animal-defined daily dosage of antimicrobials per cow per year around the dry period if a BDCT or SDCT approach is used, adjusting for the risk of cases of clinical mastitis in the next lactation for the SDCT approach. The point prevalence of IMI at the last test-day before dry-off varied between 15.0 % and 54 % for primiparous and 34.0 % and 85 % for multiparous cows, depending on the scenario. By extrapolating our results obtained from using data from dairies enrolled in the DHIA testing program for the western US, we demonstrated that regardless of the criteria used to classify cows as high risk of IMI at dry-off (scenarios 1-5), if selective dry cow therapy is adopted in the US, the dairy industry could reduce the use of antimicrobials around the dry-off between 31 % and 66 %. Multiparous cows had greater odds of being classified as high-risk than primiparous cows. Cows dried off in the spring, summer, and fall had lower odds of being classified as high-risk compared to cows dried off in the winter. Advanced days in milk at dry-off was associated with greater risk of IMI at dry-off. Greater milk yield and higher protein percentage at the last test-day before dry-off were associated with decreased odds of a cow being classified as high-risk at dry-off, cows in small herds had greater odds of being classified as high-risk at dry-off, and a variation among states was observed.

Keywords: Antimicrobial use; Dry-off; Intramammary infection; Selective dry cow therapy.