Stevens-Johnson syndrome in children

Curr Opin Pediatr. 2022 Aug 1;34(4):341-348. doi: 10.1097/MOP.0000000000001146.


Purpose of review: The concept of Stevens-Johnson syndrome (SJS) in children is evolving. This manuscript reviews recent advances with the lens of new terminology namely infection-triggered reactive infectious mucocutaneous eruption and drug-induced epidermal necrolysis, with the objective of integrating this novel terminology practically.

Recent findings: Traditionally considered to exist on a spectrum with toxic epidermal necrolysis, SJS in children is more often caused or triggered by infections instead of medications. Proposed pediatric-specific terminology can be applied to literature to gain further insights into blistering severe cutaneous adverse reactions.

Summary: Distinguishing infection-triggered from drug-triggered blistering reactions is useful for 3 main reasons: (1) early clinically recognizable different features such as isolated or predominant mucositis, (2) different initial management depending on trigger, (3) avoiding the label of a drug reaction on cases triggered by infection.

Publication types

  • Review

MeSH terms

  • Child
  • Humans
  • Stevens-Johnson Syndrome* / diagnosis
  • Stevens-Johnson Syndrome* / etiology
  • Stevens-Johnson Syndrome* / therapy