Efficacy of adenosylmethionine combined with Si Mo Tang in treatment of neonatal jaundice

Ling Li; Jingqun Wang; Shuxia Geng; Fang Liu; Lili Ping; Xiaohong Gu; Xueai Fan; Mei Yang; Lixia Liang; Wei Guo

Efficacy of adenosylmethionine combined with Si Mo Tang in treatment of neonatal jaundice

Am J Transl Res. 2022 Jun 15;14(6):3926-3935. eCollection 2022.

Authors

Ling Li¹, Jingqun Wang¹, Shuxia Geng¹, Fang Liu², Lili Ping³, Xiaohong Gu⁴, Xueai Fan⁵, Mei Yang⁶, Lixia Liang⁷, Wei Guo¹

Affiliations

¹ Department of Neonatology, Xingtai People's Hospital Xingtai, Hebei, China.
² Department of Neonatology, Bethune International Peace Hospital Shijiazhuang, Hebei, China.
³ Department of Neonatology, Handan Central Hospital Handan, Hebei, China.
⁴ Department of Neonatology, Zhangjiakou Maternal and Child Health Care Hospital Zhangjiakou, Hebei, China.
⁵ Department of Neonatology, Xingtai Third Hospital Xingtai, Hebei, China.
⁶ Department of Neonatology, Baoding First Central Hospital Baoding, Hebei, China.
⁷ Department of Neonatology, Hengshui Harrison International Peace Hospital Hengshui, Hebei, China.

PMID: 35836853
PMCID: PMC9274584

Abstract

Objective: To investigate the efficacy of S-adenosylmethionine (SAM-e) combined with Si Mo Tang in the treatment of neonatal jaundice and its effect on liver function, cardiac enzymes, immune function, serum transferrin (TRF) and C-reactive protein (CRP) levels.

Methods: The clinical data of 149 infants with neonatal jaundice were collected retrospectively. The infants were grouped according to the treatment methods. All neonates were treated with blue light phototherapy. Besides, group A was treated with SAM-e, group B was treated with Si Mo Tang, and group C was treated with SAM-e combined with Si Mo Tang. The treatment efficacy, serum bilirubin level, neonatal behavioral neurological assessment (NBNA) score, liver function, cardiac enzymes, immune function, serum TRF and CRP level were compared among the three groups before and after treatment.

Results: The total effective rate of treatment in group C was 96.00%, which was higher than group A (73.47%) and group B (78.00%) (P < 0.05), but no significant difference was observed between groups A and B (P > 0.05). Compared with groups A and B, group C had higher NBNA scores, lower serum bilirubin levels, and lower serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase-MB (CK-MB) levels (all P < 0.05); however, there was no statistical differences in NBNA scores, serum bilirubin levels, serum AST and ALT, LDH, CK and CK-MB levels between group A and group B (all P > 0.05). Compared with groups A and B, group C showed higher CD4⁺, CD4⁺/CD8⁺, TRF levels and lower serum CRP levels (P < 0.05), while there was no statistical differences in CD4⁺, CD4⁺/CD8⁺, CD8⁺, TRF levels and serum CRP levels between group A and group B (all P > 0.05).

Conclusion: SAM-e combined with Si Mo Tang promoted the regression of jaundice, improved liver function, neurodevelopmental conditions and the myocardial enzyme spectrum, reduced the level of inflammation, and improved the immunity of newborns with neonatal jaundice.

Keywords: Adenosylmethionine; C-reactive protein; Si Mo Tang; cardiac enzymes; immune function; liver function; neonatal jaundice; transferrin.