Germ cell tumors of the ovary: the experience of the National Cancer Institute of Milan. I. Dysgerminoma

Int J Radiat Oncol Biol Phys. 1987 Jun;13(6):853-60. doi: 10.1016/0360-3016(87)90099-x.


The experience of the Istituto Nazionale Tumori of Milan on dysgerminoma is presented. Between 1970 and December of 1982, 25 patients were treated with a unique protocol which considered surgery and radiotherapy with different schedules according to the extension of the disease. With this treatment protocol all 13 patients at Stage I were alive and free of disease with a median follow-up of 77 months. Of 12 patients at Stage III (10 retroperitoneal and 2 retroperitoneal and peritoneal) 4 relapsed. The 5-year relapse-free survival of Stage III patients was 61.4% and the overall survival 89.5%. Amenorrhea due to radiation dose absorbed by the contralateral shielded ovary was found in 7.7%. The excellent results in Stage I patients were balanced by the unsatisfactory results in Stage III patients. A more aggressive treatment and the knowledge of other prognostic factors seem necessary.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Combined Modality Therapy
  • Dysgerminoma / radiotherapy
  • Dysgerminoma / surgery
  • Dysgerminoma / therapy*
  • Female
  • Humans
  • Ovarian Neoplasms / radiotherapy
  • Ovarian Neoplasms / surgery
  • Ovarian Neoplasms / therapy*
  • Prognosis