Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation

Appl Radiat Isot. 2022 Oct;188:110364. doi: 10.1016/j.apradiso.2022.110364. Epub 2022 Jul 8.

Abstract

Monte Carlo simulation method and Nuclear Medicine MIRD method were used to evaluate the effect of radiopharmaceuticals on Covid-19 disease. The mean absorbed organ dose in the target organ and gamma radiation emitter attenuation properties such as linear attenuation coefficients, energy absorption build-up factors (EABF), exposure build-up factors (EBF), and relative dose distributions (RDD) were examined. The results showed that radiopharmaceuticals containing gamma radiation emitters which are densely ionizing charged particles induced membrane damage and produced protein damage.

Keywords: Covid-19; Gamma radiation emitter; Monte Carlo simulation; Relative dose distribution; Tc-99m.

MeSH terms

  • COVID-19*
  • Computer Simulation
  • Humans
  • Monte Carlo Method
  • Radiometry / methods
  • Radiopharmaceuticals* / therapeutic use

Substances

  • Radiopharmaceuticals