Roles and Molecular Mechanisms of Physical Exercise in Sepsis Treatment

You Wu; Xiaofeng Guo; Yuliang Peng; Zongping Fang; Xijing Zhang

doi:10.3389/fphys.2022.879430

Roles and Molecular Mechanisms of Physical Exercise in Sepsis Treatment

Front Physiol. 2022 Jun 29:13:879430. doi: 10.3389/fphys.2022.879430. eCollection 2022.

Authors

You Wu¹, Xiaofeng Guo^{1

2}, Yuliang Peng¹, Zongping Fang¹, Xijing Zhang¹

Affiliations

¹ Department of Intensive Care Unit, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
² Department of Intensive Care Unit, Joint Logistics Force No. 988 Hospital, Zhengzhou, China.

Abstract

Physical exercise is a planned, purposeful action to keep a healthy lifestyle and improve physical fitness. Physical exercise has been widely used as a non-pharmacological approach to preventing and improving a wide range of diseases, including cardiovascular disease, cancer, metabolic disease, and neurodegenerative disease. However, the effects of physical exercise on sepsis have not been summarized until now. In this review, we discuss the effects of physical exercise on multiple organ functions and the short- and long-time outcomes of sepsis. Furthermore, the molecular mechanisms underlying the protective effects of physical exercise on sepsis are discussed. In conclusion, we consider that physical exercise may be a beneficial and non-pharmacological alternative for the treatment of sepsis.

Keywords: molecular mechanism; organ failure; outcome; physical exercice; sepsis.

Publication types

Review