No Effect on Tumorigenesis in MG63 Cells Induced by Co-Cultured Mesenchymal Stem Cells

Xin Xing; Yue-Hua Hu; Yan Wang; Yi Shao; Min Zou

doi:10.1155/2022/4202439

No Effect on Tumorigenesis in MG63 Cells Induced by Co-Cultured Mesenchymal Stem Cells

J Oncol. 2022 Jul 6:2022:4202439. doi: 10.1155/2022/4202439. eCollection 2022.

Authors

Xin Xing¹, Yue-Hua Hu², Yan Wang³, Yi Shao⁴, Min Zou⁵

Affiliations

¹ Department of Orthopaedics Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, China.
² Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China.
³ Obstetrics and Gynecology Department, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
⁴ Orthopaedic Institute of Hebei Province, Shijiazhuang 050000, China.
⁵ Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang 050000, China.

Abstract

Osteosarcoma is a kind of bone tumor with an extremely high malignant degree and often occurs in adolescents. Mesenchymal stem cells are believed to play an important role in the microenvironment of osteosarcoma, but whether they promote or inhibit the development of osteosarcoma is controversial. In this study, the coexpression of mesenchymal stem cells (MSCs) with osteosarcoma cell MG63 was used to explore the effect of MSCs on MG63. We found that co-culture of MSCs with MG63 did not affect the proliferation, invasion, and migration of MG63 cells, nor did it significantly affect the epithelial- and glial-mesenchymal transformation of MG63 cells. Therefore, in this study, we obtained a new concept that MSCs neither promote nor inhibit the occurrence and development of osteosarcoma.